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KMID : 0379520070230040289
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한국독성학회지
2007 Volume.23 No. 4 p.289 ~ p.299
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Effects of Lipopolysaccharide on Pharmacokinetics of Drugs
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Yang Kyung-Hee
Lee Myung-Gull
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Abstract
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Lipopolysaccharide (LPS) endotoxin is an active component in the outer membrance of Gram-nega-tive bacteria. LPS is usually used as an inflammatory animal model. During the inflammation, diar-rhea and changes in plasma proteins, in hepatic and/or intestinal microsomal cytochrome P450 (CYP) isozymes, and in the renal and/or biliary excretion of drugs have been reported. Thus, in rats pretreated with lipopolysaccharide endotoxin isolated from Klebsiella pneumoniae (KPLPS rats), the absorption, distribution, metabolism, and excretion of drugs could be expected to be altered. Inter-estingly time-dependent effects on the hepatic CYP isozymes have been reported in KPLPS rats. Thus, in KPLPS rats, the pharmacokinetics of drugs which are mainly metabolized via CYP isozymes could be expected to be time-depemdent. In this review, an attempt to explain changes in pharmacokinetics of drug reported in the literacture was made in terms of CYP isozyme changes or urimary and/or biliary excretion changes in KPLPS rats.
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KEYWORD
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Polyglucosamine, PGB-1, Polymer, Enterobacter, Single oral dose toxicity, Mice, Histopathology
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